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# Chemical Checker
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The Chemical Checker (CC) is a data-driven resource of small molecule bioactivity data. The main goal of the CC is to express data in a format that can be used off-the-shelf in daily computational drug discovery tasks. The resource is organized in five levels of increasing complexity, ranging from the chemical properties of the compounds to their clinical outcomes. In between, we consider targets, off-targets, perturbed biological networks and several cell-based assays, including gene expression, growth inhibition and morphological profiles. The CC is different to other integrative compounds database in almost every aspect. The classical, relational representation of the data is surpassed here by less explicit, machine-learning oriented abstractions of the data (see the CC [Manifesto](manifesto)).
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The Chemical Checker (CC) is a data-driven resource of small molecule bioactivity data. The main goal of the CC is to express data in a format that can be used off-the-shelf in daily computational drug discovery tasks. The resource is organized in **5 levels** of increasing complexity, ranging from the chemical properties of the compounds to their clinical outcomes. In between, we consider targets, off-targets, perturbed biological networks and several cell-based assays, including gene expression, growth inhibition, and morphological profiles. The CC is different to other integrative compounds database in almost every aspect. The classical, relational representation of the data is surpassed here by less explicit, machine-learning oriented abstractions of the data (see the CC [Manifesto](manifesto)).
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The CC is an ever-growing resource maintained by the [Structural Bioinformatics & Network Biology Laboratory](http://sbnb.irbbarcelona.org) at the Institute for Research in Biomedicine [IRB Barcelona](http://irbbarcelona.org). Should you have any inquiries, please send an email to [miquel.duran@irbbarcelona.org](miquel.duran@irbbarcelona.org).
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The CC is an ever-growing resource maintained by the [Structural Bioinformatics & Network Biology Laboratory](http://sbnb.irbbarcelona.org) at the Institute for Research in Biomedicine ([IRB Barcelona](http://irbbarcelona.org)). Should you have any inquiries, please send an email to [miquel.duran@irbbarcelona.org](miquel.duran@irbbarcelona.org).
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The CC was first released to the scientific community in the following paper: [Duran-Frigola et al., *Expanding the small molecule similarity principle to all levels of biology* (2019)](https://www.dropbox.com/s/x2rqszfdfpqdqdy/duranfrigola_etal_ms_current.pdf?dl=0), and has since produced a number of [related publications](publications).
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