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Update similarity and connectivity authored by Miquel Duran-Frigola's avatar Miquel Duran-Frigola
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similarity-and-connectivity.md
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...@@ -4,6 +4,8 @@ The CC is based upon the similarity principle, i.e. similar molecules have simil ...@@ -4,6 +4,8 @@ The CC is based upon the similarity principle, i.e. similar molecules have simil
When it comes to **comparing molecules to other biological entities** (antibodies, shRNAs, diseases, etc.), the similarity principle can be generalized to the notion of **connectivity**. A classical view of connectivity are molecules that *mimic* the transcriptional profile of a shRNA experiment, or molecules that *revert* the transcriptional profile of a disease state. When it comes to **comparing molecules to other biological entities** (antibodies, shRNAs, diseases, etc.), the similarity principle can be generalized to the notion of **connectivity**. A classical view of connectivity are molecules that *mimic* the transcriptional profile of a shRNA experiment, or molecules that *revert* the transcriptional profile of a disease state.
![ConnectivityFigure-01](uploads/26badf8d3d8ac869c56b154a1be285f8/ConnectivityFigure-01.png)
These are some ways similarity and connectivity can be applied in the CC: These are some ways similarity and connectivity can be applied in the CC:
![Artboard_1](/uploads/f40cdd77b699598f218679922bbfaf92/Artboard_1.png) ![Artboard_1](/uploads/f40cdd77b699598f218679922bbfaf92/Artboard_1.png)
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